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Model based reconstruction for simultaneously imaging cerebral blood flow and De-oxygen hemoglobin distribution

By: Peng Miao; Nan Li; Rege, A.; Shanbao Tong; Thakor, N.;

2009 / IEEE / 978-1-4244-3296-7

Description

This item was taken from the IEEE Conference ' Model based reconstruction for simultaneously imaging cerebral blood flow and De-oxygen hemoglobin distribution ' Laser speckle imaging (LSI) and optical intrinsic signal (OIS) imaging are shown to produce high resolution information of cerebral blood flow(CBF) and de-oxygen hemoglobin(dHb) respectively. However, the cortex curvature and non-uniform illumination always result in the inhomo-geneous impact and thus distort the CBF and dHb results. In this paper, we propose to extract both CBF and dHb images from raw speckle images. A parametric model for such inhomogeneity is estimated by adaptive window median-mean filtering and curve fitting technique to reconstruct the CBF and dHb image.