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Accuracy of noninvasive quantification of brain NAA concentrations using PRESS sequence: verification in a swine model with external standard
By: Luo, W.H.; Rao, H.B.; Lin, R.; Xiao, Z.W.; Li, H.; Guo, G.; Wu, R.H.; Lang, Z.J.; Zhang, X.G.; Huang, K.;
2005 / IEEE / 0-7803-8741-4
This item was taken from the IEEE Conference ' Accuracy of noninvasive quantification of brain NAA concentrations using PRESS sequence: verification in a swine model with external standard ' The metabolite ratios had been employed in the field of MR spectroscopy (MRS) for a long period. The main drawback of metabolite ratio is that ratio results are not comparable with absolute metabolite concentration in vivo. The purpose of this study was to examine the accuracy of noninvasive quantification of brain N-Acetylaspartate (NAA) concentrations using previously reported MR external standard method. Eight swine were scanned on a GE 1.5 T scanner with a standard head coil. The external standard method was utilized with a sphere filled with NAA, GABA, glutamine, glutamate, creatine, choline chloride, and myo-inositol. The position resolved spectroscopy (PRESS) sequence was used with TE=135 msec, TR=1500 msec, and 128 scan averages. The analysis of MRS was done with SAGE/IDL program. In vivo NAA concentration was obtained using the equation S= N e(-TE/T
High Performance Liquid Chromatography
N-acetyl Resonance Frequencies
N-acetylated Amino Acids
Magnetic Resonance Spectroscopy
Position Resolved Spectroscopy Sequence
Noninvasive Brain Naa Concentration Quantification