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Expediting magnetic separation using Ni Wires,Applicable for robot-manipulated bio-screening systems

By: Abe, M.; Handa, H.; Matsushita, N.; Tada, M.; Shimazu, R.;

2005 / IEEE

Description

This item was taken from the IEEE Periodical ' Expediting magnetic separation using Ni Wires,Applicable for robot-manipulated bio-screening systems ' We developed a novel millimeter sized high gradient magnetic separation (HGMS) device for robot-manipulated bio-screening systems where test liquids containing magnetic nanobeads are processed in mm-sized container arrays in wells. Two hundred Ni wires (200/spl mu/m/spl phi//spl times/ 30mm) were bundled together to make a tubular brush (6.7mm and 8.4mm in inner and outer diameters), which was set in a container (8.8mm/spl phi//spl times/ 45mm in inner size) to enhance the magnetic field gradient. Application of an external field of 0.3T (a value attainable using NdFeB magnets) enabled separation of magnetic particles having an average diameter of 30nm, at a recapture rate of 98%, in three minutes. Theoretical calculations based on a simple model confirmed the validity of the results.